Cyril Dominguez

Mechanism of heme binding by CP motifs in the BACH1 DNA-binding region

This study investigates how heme binds to BACH1's CP motifs and how this affects DNA dissociation, revealing that multiple residues contribute to heme binding and DNA release.

Direct observation of conformational dynamics in intrinsically disordered proteins at the single-molecule level

This paper observes conformational dynamics of unmodified IDPs/IDRs at the single-molecule level using nanoaperture optical tweezers, revealing increased conformational variation and phosphorylation-induced compaction.

Constitutively active RAS prolongs Cdc42 signalling while attenuating MAPK signalling during fission yeast mating

This study shows that constitutively active RAS in fission yeast prolongs Cdc42 signaling while reducing MAPK signaling through competitive binding and feedback mechanisms.

A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export suppresses neurodegeneration

This paper develops a cell-penetrant peptide that blocks C9ORF72-repeat RNA nuclear export, reducing neurodegeneration in preclinical models of ALS and FTD.

Cdk1-mediated threonine phosphorylation of Sam68 modulates its RNA binding, alternative splicing activity, and cellular functions

This study identifies Cdk1-mediated phosphorylation of Sam68 at T33 and T317, showing it reduces RNA binding and alternative splicing activity, promoting cell proliferation and inhibiting apoptosis in HCT116 cells.

Constitutively active RAS in S. pombe causes persistent Cdc42 signalling but only transient MAPK activation

The paper shows that constitutively active Ras1.G17V in S. pombe causes prolonged Cdc42 activation but only transient MAPKSpk1 activation, with a model explaining the dynamics.