The density of regulatory information is a major determinant of evolutionary constraint on non-coding DNA in Drosophila
Gonzalo Sabarís, Daniela M. Ortíz, Ian Laiker, Ignacio Mayansky, Sujay Naik, Giacomo Cavalli, David L. Stern, Ella Preger‐Ben Noon, Nicolás Frankel
The paper investigates the relationship between regulatory information density and evolutionary constraint in non-coding DNA of Drosophila, finding that dense regulatory regions contribute significantly to constraint.
Molecular Biology and Evolution · Feb 1, 2024Peer-reviewedGenetics