Nicolás Frankel

The paper shows how four distinct mechanisms inactivate redundant enhancers of the shavenbaby gene in Drosophila sechellia, leading to the loss of larval trichomes.

The paper characterizes a new Escherichia cryptic clade IV strain from an urban stream, revealing genomic features linked to environmental adaptation and ecological origin.

The paper investigates the relationship between regulatory information density and evolutionary constraint in non-coding DNA of Drosophila, finding that dense regulatory regions contribute significantly to constraint.

The paper identifies pleiotropic enhancers in the human genome using eRNA and chromatin data, showing most enhancers are active in multiple organs and are subject to evolutionary constraints.

The paper investigates enhancer pleiotropy in D. melanogaster, showing that multiple enhancers of the shavenbaby gene drive expression across tissues and developmental stages through distinct or shared transcription factor binding sites.

The paper describes genetic and transgenic reagents for several Drosophila species to facilitate genetic studies.