Epigenetic Modulation to perturb the SYNGAP1 Intellectual Disability (ID) that ameliorates synaptic and behavioural deficits
Akash Kumar Singh, Ila Joshi, Neeharika M. N. Reddy, Sushmitha S. Purushotham, Muthusamy Eswaramoorthy, Madavan Vasudevan, Sourav Banerjee, J. P Clement, Tapas Kumar Kundu
This study shows that modulating histone acetylation with a small molecule activator improves synaptic and behavioural deficits in a SYNGAP1 mutation model.
bioRxiv · Jan 3, 2024 · PreprintNeuroscience