James Premdoss Clement

This study shows that deleting SRF in astrocytes creates neuroprotective astrocytes that reduce neuronal damage in mouse models of excitotoxicity and neurodegenerative diseases.

This study shows oral administration of CSP-TTK21 achieves synaptic plasticity and spinal cord injury repair effects similar to intraperitoneal delivery in mice and rats.

This study identifies TGR63, a naphthalene monoimide derivative, as a promising therapeutic for Alzheimer's disease by reducing amyloid burden and cognitive decline in a mouse model.

This study shows that chronic chemogenetic activation of forebrain excitatory neurons during postnatal life leads to long-lasting mood-related behavioral and neurophysiological changes.

The paper identifies a translation-dependent degradation axis involving miRISC remodeling that drives synaptic homeostasis through the interplay of protein synthesis and degradation.

The paper investigates how different doses of CNO affect excitatory neurotransmission in the hippocampus using hM3Dq DREADD activation in mice.

This study shows that reduced FMRP expression in Syngap1+/− mice leads to increased Syngap1 translation and altered eEF2 phosphorylation via NMDA receptor signaling.