Multigenerational Proteolytic Inactivation of Restriction Upon Subtle Genomic Hypomethylation
Esther Shmidov, Alexis Villani, Senén D. Mendoza, Ellay Avihu, Ilana Lebenthal-Loinger, Sarit Karako‐Lampert, Sivan Shoshani, Chang Ye, Yiding Wang, Hao Yan, Weixin Tang, Joseph Bondy‐Denomy, Ehud Banin
This study shows that Pseudomonas aeruginosa inactivates its type I R-M system via proteolysis at high temperatures, leading to prolonged genomic hypomethylation and a memory effect lasting over 60 generations.
Nature Microbiology · Sep 8, 2025Peer-reviewedMicrobiology