GDNF receptor agonist supports dopamine neurons in vitro and protects their function in animal model of Parkinson's disease.
Arun Kumar Mahato, Juho‐Matti Renko, Jaakko J. Kopra, Tanel Visnapuu, Ilari Korhonen, Nita Pulkkinen, Maxim M. Bespalov, Eric Ronken, Petteri T. Piepponen, Merja H. Voutilainen, Raimo K. Tuominen, Mati M. Karelson, Yulia A. Sidorova, Märt Saarma
The paper shows that BT13, a GDNF receptor agonist, supports dopamine neuron survival in vitro and protects their function in a Parkinson's disease rat model by crossing the blood-brain barrier.
bioRxiv · Feb 4, 2019 · PreprintNeuroscience