Author

Merja H. Voutilainen

University of HelsinkiORCID 0000-0002-9832-7655Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:rat· 3 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Märt SaarmaiD· 4 shared Jin Han NamiD· 3 shared Mati M. KarelsoniD· 2 shared Michael SendtneriD· 2 shared Päivi LindholmiD· 2 shared Patrick LüningschröriD· 2 shared Anu Hyysalo· 1 shared Arun Kumar MahatoiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersNeuroscience

Märt SaarmaORCID

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4 papers

Recent·Most cited

Non-invasive peripheral delivery of CDNF fragment protects neurons in models of Parkinsons and ALS

Li Ying Yu, Tuulikki Viljakainen, Liam Beckett, Jin Han Nam, Anu Hyysalo, Patrick Lüningschrör, Katrina Albert, Tapani K Koppinen, Tanja Hyvärinen, Helena Tossavainen, Maarit Hellman, Mikko Airavaara, Michael Sendtner, Perttu Permi, Päivi Lindholm, , Merja H. Voutilainen

This paper demonstrates that a novel C-CDNF fragment can protect neurons in Parkinson's and ALS models through non-invasive peripheral delivery.

bioRxiv · Feb 9, 2025 · PreprintNeuroscience

Small molecule activation of m6A mRNA methylation as a novel approach for neuroprotection

Li-Ying Yu, Simona Selberg, Indrek Teino, Jin Han Nam, Larisa B. Ivanova, Brunaldo Renzi, Neinar Seli, Esko M Kankuri, Merja H. Voutilainen, Mati M. Karelson, Märt Saarma

The paper identifies small molecule activators of m6A mRNA methylation that protect and regenerate dopamine neurons in Parkinson's disease models.

bioRxiv · Jul 5, 2023 · PreprintNeuroscience

CDNF rescues motor neurons in three animal models of ALS by targeting ER stress

Francesca De Lorenzo, Patrick Lüningschrör, Jin Han Nam, Federica Pilotto, Emilia Galli, Päivi Lindholm, Cora R. von Collenberg, Simon Tii Mungwa, Sibylle Jablonka, Julia Kauder, Susanne Petri, Dan Lindholm, Smita Saxena, Michael Sendtner, Märt Saarma, Merja H. Voutilainen

This study shows CDNF reduces ER stress and improves motor neuron survival in multiple ALS models, independent of genetic cause.

bioRxiv · May 5, 2020 · PreprintNeuroscience

GDNF receptor agonist supports dopamine neurons in vitro and protects their function in animal model of Parkinson's disease.

Arun Kumar Mahato, Juho‐Matti Renko, Jaakko J. Kopra, Tanel Visnapuu, Ilari Korhonen, Nita Pulkkinen, Maxim M. Bespalov, Eric Ronken, Petteri T. Piepponen, Merja H. Voutilainen, Raimo K. Tuominen, Mati M. Karelson, Yulia A. Sidorova, Märt Saarma

The paper shows that BT13, a GDNF receptor agonist, supports dopamine neuron survival in vitro and protects their function in a Parkinson's disease rat model by crossing the blood-brain barrier.

bioRxiv · Feb 4, 2019 · PreprintNeuroscience