Petteri T. Piepponen

This study investigates the role of GLE1 in cellular homeostasis and development, showing that its dysfunction leads to embryonic lethality and mid-adulthood death in mice, with defects in neural crest-derived tissues and stress responses.

This study shows that GDNF regulates serotonin system development and adult function, with excess GDNF linked to neuropsychiatric disorders.

This study shows that impaired astrocytic GABA transport in Fragile X syndrome contributes to hyperexcitability and behavioral abnormalities, and blocking this transport can restore normal function.

This study shows that nicotinamide riboside (NR) alleviates Parkinson's disease symptoms in animal models but reduces dopamine levels when combined with proteasome inhibition.

This study identifies a direct binding of antidepressants to TRKB receptors, revealing a mechanism linking molecular interactions to antidepressant effects.

This study describes a protocol to generate hindbrain-like human brain organoids with mature, functional neurons and reports their response to Zika virus and anticonvulsants.

This paper develops methods to upregulate gene expression in vivo while preserving cell-type-specific regulation, demonstrating their use in studying gene function and disease mechanisms.

The paper shows that BT13, a GDNF receptor agonist, supports dopamine neuron survival in vitro and protects their function in a Parkinson's disease rat model by crossing the blood-brain barrier.