Author

Jaakko J. Kopra

University of HelsinkiORCID 0000-0002-4872-3326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:rat· 1

Frequent Co-Authors

Petteri T. PiepponeniD· 3 shared Ana Montaño-RodrigueziD· 2 shared Daniel R. GartoniD· 2 shared Jaan‐Olle AndressooiD· 2 shared Kärt MätlikiD· 2 shared Anastasios E. DamdimopoulosiD· 1 shared Anne E. PanhelaineniD· 1 shared Arun Kumar MahatoiD· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Petteri T. PiepponenORCID

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3 papers

Recent·Most cited

Serotonin system development and adult function are regulated by GDNF

Daniel R. Garton, Isabel Runneberger, Laoise Casserly, Tabea Schorling, Ana Montaño-Rodriguez, Vilma Iivananen, Jaakko J. Kopra, Kärt Mätlik, Fredrik Fagerström‐Billai, Anastasios E. Damdimopoulos, Petteri T. Piepponen, Jaan‐Olle Andressoo

This study shows that GDNF regulates serotonin system development and adult function, with excess GDNF linked to neuropsychiatric disorders.

bioRxiv · Dec 11, 2024 · PreprintNeuroscience

Gene Knock Up via 3’UTR editing to study gene function in vivo

Kärt Mätlik, Soophie Olfat, Daniel R. Garton, Ana Montaño-Rodriguez, Giorgio Turconi, L. Lauriina Porokuokka, Anne E. Panhelainen, Nadine Schweizer, Jaakko J. Kopra, Mark Cary Cowlishaw, Petteri T. Piepponen, Fuping Zhang, Petra Sipilä, Johan Jakobsson, Jaan‐Olle Andressoo

This paper develops methods to upregulate gene expression in vivo while preserving cell-type-specific regulation, demonstrating their use in studying gene function and disease mechanisms.

bioRxiv · Sep 23, 2019 · PreprintNeuroscience

GDNF receptor agonist supports dopamine neurons in vitro and protects their function in animal model of Parkinson's disease.

Arun Kumar Mahato, Juho‐Matti Renko, Jaakko J. Kopra, Tanel Visnapuu, Ilari Korhonen, Nita Pulkkinen, Maxim M. Bespalov, Eric Ronken, Petteri T. Piepponen, Merja H. Voutilainen, Raimo K. Tuominen, Mati M. Karelson, Yulia A. Sidorova, Märt Saarma

The paper shows that BT13, a GDNF receptor agonist, supports dopamine neuron survival in vitro and protects their function in a Parkinson's disease rat model by crossing the blood-brain barrier.

bioRxiv · Feb 4, 2019 · PreprintNeuroscience