Author

Mati M. Karelson

University of TartuORCID 0000-0002-9643-6380Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Organism:mouse· 2 Organism:rat· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Märt SaarmaiD· 4 shared Larisa B. IvanovaiD· 3 shared Li-Ying YuiD· 3 shared Esko M KankuriiD· 2 shared Merja H. VoutilaineniD· 2 shared Neinar Seli· 2 shared Simona SelbergiD· 2 shared Vera D. KovalevaiD· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersNeuroscience

Märt SaarmaORCID

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5 papers

Recent·Most cited

CDNF rescues human iPSCs-derived dopamine neurons through direct binding to unfolded protein response sensors PERK and IRE1α

Vera D. Kovaleva, Olesya G. Shpironok, Li-Ying Yu, Larisa B. Ivanova, Satoshi Fudo, Lotta Happonen, Urve Toots, Mart Ustav, Tommi Kajander, Mati M. Karelson, Märt Saarma

This study identifies CDNF's mechanism of action by showing it rescues human dopamine neurons through direct binding to UPR sensors PERK and IRE1α.

bioRxiv · Dec 17, 2024 · PreprintNeuroscience

USP14 regulates pS129 α-synuclein levels and oxidative stress in human SH-SY5Y dopaminergic cells

Vignesh Srinivasan, Rabah Soliymani, Larisa B. Ivanova, Ove Eriksson, Nina Peitsaro, Maciej M. Lalowski, Mati M. Karelson, Dan Lindholm

This study shows that USP14 regulates pS129 α-synuclein and oxidative stress in SH-SY5Y cells by affecting proteasome activity and reducing ROS.

bioRxiv · May 9, 2024 · PreprintNeuroscience

Small molecule activation of m6A mRNA methylation as a novel approach for neuroprotection

Li-Ying Yu, Simona Selberg, Indrek Teino, Jin Han Nam, Larisa B. Ivanova, Brunaldo Renzi, Neinar Seli, Esko M Kankuri, Merja H. Voutilainen, Mati M. Karelson, Märt Saarma

The paper identifies small molecule activators of m6A mRNA methylation that protect and regenerate dopamine neurons in Parkinson's disease models.

bioRxiv · Jul 5, 2023 · PreprintNeuroscience

Small-molecule inhibitors of the RNA m6A demethylase FTO potently support the survival of dopamine neurons

Simona Selberg, Li-Ying Yu, Olesja M. Bondarenko, Esko M Kankuri, Neinar Seli, Vera D. Kovaleva, Koit Herodes, Märt Saarma, Mati M. Karelson

This study develops small-molecule FTO inhibitors that enhance dopamine neuron survival and show BBB penetration, with greater potency than existing AlkBH5 inhibitors.

International Journal of Molecular Sciences · Apr 26, 2021Peer-reviewedNeuroscience

GDNF receptor agonist supports dopamine neurons in vitro and protects their function in animal model of Parkinson's disease.

Arun Kumar Mahato, Juho‐Matti Renko, Jaakko J. Kopra, Tanel Visnapuu, Ilari Korhonen, Nita Pulkkinen, Maxim M. Bespalov, Eric Ronken, Petteri T. Piepponen, Merja H. Voutilainen, Raimo K. Tuominen, Mati M. Karelson, Yulia A. Sidorova, Märt Saarma

The paper shows that BT13, a GDNF receptor agonist, supports dopamine neuron survival in vitro and protects their function in a Parkinson's disease rat model by crossing the blood-brain barrier.

bioRxiv · Feb 4, 2019 · PreprintNeuroscience