Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Gois, Rosalie A. Kampen, Marta San Martín Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M.F. Wolthuis, Sylvie M. Noordermeer
This study compares synthetic lethal interactions in hypomorphic BRCA1 missense mutations to BRCA1-depleted cells, revealing distinct vulnerabilities for BRCA1R1699Q mutations.
Molecular Oncology · May 29, 2026Peer-reviewedCancer Biology