Author

Tiemen J. Wendel

Leiden University Medical CenterORCID 0009-0006-1434-2396Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Marta San Martín AlonsoiD· 2 shared Sylvie M. NoordermeeriD· 2 shared Veronica Garzero· 2 shared A. Schreuder· 1 shared André NussenzweigiD· 1 shared Anne SchreuderiD· 1 shared Arne van HoeckiD· 1 shared Bert van de KooijiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Marta San Martín AlonsoORCID

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2 papers

Recent·Most cited

Cancer BiologyMolecular OncologyPeer-reviewedMay 29, 2026

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ…·Sylvie M. Noordermeer

This study compares synthetic lethal interactions in hypomorphic BRCA1 missense mutations to BRCA1-depleted cells, revealing distinct vulnerabilities for BRCA1R1699Q mutations.

DOI 10.1002/1878-0261.70271

humanCRISPR screen

𝕏 PostBluesky

Molecular BiologybioRxivPreprintFeb 24, 2023

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

Bert van de Kooij, A. Schreuder, Raphael Pavani…·Sylvie M. Noordermeer

This study shows that EXO1 is essential for survival of BRCA1-deficient cells and identifies it as a potential therapeutic target.

4 citations

humanexperimental assay

𝕏 PostBluesky