Author

Anne Schreuder

Leiden University Medical CenterORCID 0000-0002-2268-0735Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Marta San Martín AlonsoiD· 2 shared Rosalie A. KampeniD· 2 shared Sylvie M. NoordermeeriD· 2 shared Veronica Garzero· 2 shared Arnoud H. de RuiD· 1 shared Daniel Salas‐LloretiD· 1 shared Hồ Mỹ Phúc VõiD· 1 shared Ilse Nootenboom· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Marta San Martín AlonsoORCID

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2 papers

Recent·Most cited

DNA end-resection is stimulated by an interaction between BRCA1 exon 11 and TOPBP1

Marta San Martín Alonso, Rosalie A. Kampen, Anne Schreuder, Daniel Salas‐Lloret, Arnoud H. de Ru, Veronica Garzero, Romy L.S. Mesman, Román González‐Prieto, Peter A. van Veelen, Sylvie M. Noordermeer

The paper identifies a DNA damage- and phospho-dependent interaction between BRCA1 exon 11 and TOPBP1, showing its role in end-resection during homologous recombination.

EMBO Reports · Aug 27, 2026Peer-reviewedMolecular Biology

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Gois, Rosalie A. Kampen, Marta San Martín Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M.F. Wolthuis, Sylvie M. Noordermeer

This study compares synthetic lethal interactions in hypomorphic BRCA1 missense mutations to BRCA1-depleted cells, revealing distinct vulnerabilities for BRCA1R1699Q mutations.

Molecular Oncology · May 29, 2026Peer-reviewedCancer Biology