Author
Leiden University Medical CenterORCID 0000-0003-2737-9690Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
Recent·Most cited
Marta San Martín Alonso, Rosalie A. Kampen, Anne Schreuder…·Sylvie M. Noordermeer
The paper identifies a DNA damage- and phospho-dependent interaction between BRCA1 exon 11 and TOPBP1, showing its role in end-resection during homologous recombination.
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ…·Sylvie M. Noordermeer
This study compares synthetic lethal interactions in hypomorphic BRCA1 missense mutations to BRCA1-depleted cells, revealing distinct vulnerabilities for BRCA1R1699Q mutations.
Mariana Marcela Góis, Lais Bonafe, L O Silva…·Fernando Moreira Simabuco
This study shows that S6K1 and S6K2 regulate BRCA1 stability and HR repair, with their double knockout increasing DNA damage sensitivity and genomic instability.
Bert van de Kooij, A. Schreuder, Raphael Pavani…·Sylvie M. Noordermeer
This study shows that EXO1 is essential for survival of BRCA1-deficient cells and identifies it as a potential therapeutic target.
Alana Sherker, Natasha Chaudhary, Salomé Adam…·Daniel Durocher
This study identifies two redundant ubiquitin-dependent pathways for BRCA1 localization to DNA damage sites, involving RAP80 and the BRCA1 RING domain.
Yana van der Weegen, Klaas de Lint, Diana van den Heuvel…·Martijn S. Luijsterburg
This study identifies ELOF1 as a factor that directs CRL4CSA to ubiquitylate RNAPII at K1268, facilitating TCR and protecting CSB-deficient cells from transcription-replication collisions.