Author
Leiden University Medical CenterORCID 0000-0001-9781-864XUnclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Marta San Martín Alonso, Rosalie A. Kampen, Anne Schreuder…·Sylvie M. Noordermeer
The paper identifies a DNA damage- and phospho-dependent interaction between BRCA1 exon 11 and TOPBP1, showing its role in end-resection during homologous recombination.
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ…·Sylvie M. Noordermeer
This study compares synthetic lethal interactions in hypomorphic BRCA1 missense mutations to BRCA1-depleted cells, revealing distinct vulnerabilities for BRCA1R1699Q mutations.
Bert van de Kooij, A. Schreuder, Raphael Pavani…·Sylvie M. Noordermeer
This study shows that EXO1 is essential for survival of BRCA1-deficient cells and identifies it as a potential therapeutic target.
Yana van der Weegen, Klaas de Lint, Diana van den Heuvel…·Martijn S. Luijsterburg
This study identifies ELOF1 as a factor that directs CRL4CSA to ubiquitylate RNAPII at K1268, facilitating TCR and protecting CSB-deficient cells from transcription-replication collisions.