DISCO-seq: 3D single-cell transcriptomics of intact biological systems
Harsharan S. Bhatia, Laurent H. A. Simons, Louis Benedikt Kuemmerle, Cristin Aubin, Sophie Martina Johanna Jansen, Zhisong He, Mayar Ali, Denise Jeridi, Mihail Ivilinov Todorov, Luciano Hoeher, Sudharsan Padmarasu, Ha Eun Park, Justus Flinn Thevis, Laura M. Bartos, Inderjeet Singh, , Ali Ertürk
DISCO-seq enables 3D single-cell transcriptomics of whole tissues and organisms by combining tissue-clearing chemistry with imaging and transcriptomic profiling.
bioRxiv · Dec 13, 2025 · PreprintSystems Biology