Siegfried Ussar

DISCO-seq enables 3D single-cell transcriptomics of whole tissues and organisms by combining tissue-clearing chemistry with imaging and transcriptomic profiling.

LipiGo is a DNA-lipid nanoparticle hybrid that enables efficient delivery of functional mRNA to non-hepatic tissues, particularly the spleen, through passive redistribution and active targeting.

The paper identifies Dpp4+ preadipocytes in pre-wean mice and shows Igf2 promotes their expansion, which drives adipogenesis.

This study uses single-cell transcriptomics to analyze neovascularization in 3D cultures of hiPSC-derived endothelial cells and mural cells, identifying cell type dynamics and interactions.

This study shows that a hypercaloric diet causes temporary molecular changes in astrocytes specifically in the arcuate nucleus of the hypothalamus.