Harsharan S. Bhatia

The paper identifies a hypervascular, BBB-compromised state in aging mice linked to cognitive decline and shows pharmacological stabilization improves vascular and cognitive outcomes.

DISCO-seq enables 3D single-cell transcriptomics of whole tissues and organisms by combining tissue-clearing chemistry with imaging and transcriptomic profiling.

This paper introduces MouseMapper, a deep learning tool combined with 3D imaging to analyze whole-body structural changes in obesity, revealing nerve and immune system alterations.

This study shows SARS-CoV-2 spike protein accumulates in the skull-meninges-brain axis, causing brain cell death and long-term neurological effects.

The paper introduces a new imaging technique to enhance fluorescent signal in cleared mouse bodies, enabling whole-body visualization of neuronal connectivity and trauma effects.