Mihail Ivilinov Todorov

The paper identifies a hypervascular, BBB-compromised state in aging mice linked to cognitive decline and shows pharmacological stabilization improves vascular and cognitive outcomes.

This study shows that chronic stress accelerates brain aging in young mice but activates age-specific anti-aging programs in old mice.

DISCO-seq enables 3D single-cell transcriptomics of whole tissues and organisms by combining tissue-clearing chemistry with imaging and transcriptomic profiling.

The paper shows that combining progenitor expansion with adhesion-controlled neuronal migration enhances cortex folding in mice, leading to sulci and gyri formation.

This study shows that TREM2 deficiency rescues synaptic integration and functional maturation of transplanted neurons in an inflammatory environment.

This paper introduces MouseMapper, a deep learning tool combined with 3D imaging to analyze whole-body structural changes in obesity, revealing nerve and immune system alterations.

This study compares the biodistribution of Fc-engineered molecules targeting BBB receptors with standard antibodies, showing distinct CNS and peripheral organ targeting.

DELiVR uses VR-generated data to train deep learning models for quantifying c-Fos in cleared mouse brains, revealing new activation patterns in cancer-related brain activity.

The paper develops a deep learning framework to analyze whole brain vasculature in cleared mouse brains, revealing new insights into vascular architecture and collateralization.

The paper introduces a new imaging technique to enhance fluorescent signal in cleared mouse bodies, enabling whole-body visualization of neuronal connectivity and trauma effects.