A nucleotide code governs Lis1's ability to relieve dynein autoinhibition
Indigo C. Geohring, Pengxin Chai, Bharat Ramasubramanian Iyer, William D. Ton, Jun Wei Yang, Amy H. Ide, Sydney C. George, Jaiveer S. Bagri, Samuel V. Baird, Kai Zhang, Steven M. Markus
The paper identifies nucleotide codes that regulate dynein-Lis1 binding and reveal how Lis1 relieves dynein autoinhibition through structural changes.
Nature Chemical Biology · Jan 22, 2026Peer-reviewedBiochemistry