Steven M. Markus

Asymmetric condensin loop extrusion is regulated by RPA-coated single-stranded DNA in quiescent cells

The paper investigates how RPA-coated single-stranded DNA regulates condensin loop extrusion in quiescent yeast cells, revealing asymmetric extrusion and a role for transcription-generated topological stress.

A nucleotide code governs Lis1's ability to relieve dynein autoinhibition

The paper identifies nucleotide codes that regulate dynein-Lis1 binding and reveal how Lis1 relieves dynein autoinhibition through structural changes.

Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells

This study shows that inhibiting the p38-MK2 pathway enhances the effectiveness of microtubule inhibitors in breast cancer cells while sparing normal cells.

Cryo-EM Reveals the Mechanochemical Cycle of Reactive Full-length Human Dynein-1

The paper uses cryo-EM to study the mechanochemical cycle of full-length human dynein-1, revealing over 40 high-resolution structures and new mechanistic insights.