Kai Zhang

The paper identifies nucleotide codes that regulate dynein-Lis1 binding and reveal how Lis1 relieves dynein autoinhibition through structural changes.

The paper uses in situ cryo-EM to visualize human ribosome structures and functional states, revealing new protein interactions and polysome interfaces.

The paper shows Nde1 enhances Lis1 binding to autoinhibited dynein, facilitating Phi conformation opening through a novel intermediate state.

The paper uses cryo-EM to study the mechanochemical cycle of full-length human dynein-1, revealing over 40 high-resolution structures and new mechanistic insights.

The paper identifies a novel non-motile dynein heavy chain subfamily, DNAHX, using cryo-EM and shows its evolutionary origin and structural features.

This paper uses in-situ cryo-electron microscopy to determine high-resolution structures of mitochondrial respiratory supercomplexes in their native state, revealing their organization and dynamic processes.

This study identifies PPR756 as a rice protein essential for mitochondrial RNA editing, affecting pollen development through interactions with OsMORFs.