Yue Wang

The paper uses cryo-EM to study the mechanochemical cycle of full-length human dynein-1, revealing over 40 high-resolution structures and new mechanistic insights.

This study identifies H2BC1 and H2AZ.2 as critical components of H2AK119ub nucleosomes, essential for Polycomb gene silencing.

This paper introduces AlphaFold-Eva, a deep learning method to evaluate the reliability of AlphaFold 2 predictions for unknown complex structures using intrinsic structural features.