Stereochemical identity of lipid nanoparticles modulates protein expression via internal lipid organization
Dennis Aschmann, Renzo A. Knol, Wessel Verbeet, Sven Wijngaarden, Oscar Escalona-Rayo, Rafael V. M. Freire, Karl Bertram, Indira Tekkali, Georg Bunzel, Bauke Fontein, Aiswarya Dharan, Inès Pfister, Yun Zhang, Tom Keijer, Joost N. H. Reek, , Alexander Kros
This study shows that stereochemical identity of lipid nanoparticles affects their physicochemical properties and protein expression through internal lipid organization.
bioRxiv · Jun 9, 2026 · PreprintPharmacology & Toxicology