Alexander Kros

Stereochemical identity of lipid nanoparticles modulates protein expression via internal lipid organization

This study shows that stereochemical identity of lipid nanoparticles affects their physicochemical properties and protein expression through internal lipid organization.

A single-nucleotide change in the Kozak sequence enhances protein expression

The paper identifies a single-nucleotide change in the Kozak sequence that consistently enhances protein expression across different UTR contexts and coding sequences.

A narrow thermodynamic design window governs selective membrane permeabilization and antiviral activity of amphipathic peptides

The paper identifies a narrow thermodynamic design window for amphipathic peptides to selectively permeabilize viral membranes while sparing host cells, using a physics-driven generative workflow.

The missing link between biomolecular condensates and amyloid fibrils

This paper identifies amphiphilic motifs that encode both fluid lyotropic phases and amyloid formation, linking functional condensation with pathological aggregation.