Author

Sven Wijngaarden

Leiden UniversityORCID 0000-0002-6449-4113Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

Aakrosh RataniD· 1 shared Ahmed AlmaghasilahiD· 1 shared Aiswarya DharaniD· 1 shared Alexander KrosiD· 1 shared Bauke FonteiniD· 1 shared Bram SlütteriD· 1 shared Bryce M. PaschaliD· 1 shared Chunsong YangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Aakrosh RatanORCID

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2 papers

Recent·Most cited

Stereochemical identity of lipid nanoparticles modulates protein expression via internal lipid organization

Dennis Aschmann, Renzo A. Knol, Wessel Verbeet, Sven Wijngaarden, Oscar Escalona-Rayo, Rafael V. M. Freire, Karl Bertram, Indira Tekkali, Georg Bunzel, Bauke Fontein, Aiswarya Dharan, Inès Pfister, Yun Zhang, Tom Keijer, Joost N. H. Reek, , Alexander Kros

This study shows that stereochemical identity of lipid nanoparticles affects their physicochemical properties and protein expression through internal lipid organization.

bioRxiv · Jun 9, 2026 · PreprintPharmacology & Toxicology

Parp7 generates an ADP-ribosyl degron that controls negative feedback of androgen signaling

Krzysztof Wierbiłowicz, Chunsong Yang, Ahmed Almaghasilah, Patryk Adam Wesołowski, Philipp Pracht, Natalia M. Dworak, Jack Masur, Sven Wijngaarden, Dmitri V. Filippov, David J. Wales, Joshua B. Kelley, Aakrosh Ratan, Bryce M. Paschal

The paper identifies PARP7 as an enzyme that ADP-ribosylates the androgen receptor, marking it for degradation and creating negative feedback on AR-dependent gene expression.

The EMBO Journal · Jul 18, 2025Peer-reviewedCancer Biology