Author

Dennis Aschmann

Leiden UniversityORCID 0009-0005-8889-0515Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Approach:transformer / foundation model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Alexander KrosiD· 2 shared Aiswarya DharaniD· 1 shared Bauke FonteiniD· 1 shared Bram SlütteriD· 1 shared Georg BunzeliD· 1 shared Herre Jelger RisseladaiD· 1 shared Ilja Karina VoetsiD· 1 shared Indira Tekkali· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPharmacology & Toxicology

Alexander KrosORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintJun 9, 2026

Stereochemical identity of lipid nanoparticles modulates protein expression via internal lipid organization

Dennis Aschmann, Renzo A. Knol, Wessel Verbeet…·Alexander Kros

This study shows that stereochemical identity of lipid nanoparticles affects their physicochemical properties and protein expression through internal lipid organization.

DOI 10.64898/2026.06.05.730351

zebrafishmouse

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BiophysicsbioRxivPreprintApr 22, 2026

A narrow thermodynamic design window governs selective membrane permeabilization and antiviral activity of amphipathic peptides

Niek van Hilten, Pascal von Maltitz, Dennis Aschmann…·Herre Jelger Risselada

The paper identifies a narrow thermodynamic design window for amphipathic peptides to selectively permeabilize viral membranes while sparing host cells, using a physics-driven generative workflow.

DOI 10.64898/2026.04.20.719566

deep learningtransformer / foundation model

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