The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells
Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango‐González, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernández‐Godino, Berta de la Cerda, Simon J. Clark, Marius Ueffing
This study shows that the CFH Y402H polymorphism increases vulnerability of iPSC-RPE cells to Hydroquinone-induced oxidative stress, suggesting genetic risk predisposition rather than soluble FH effects.
Frontiers in Immunology · Feb 6, 2025Peer-reviewedCell Biology