Author

Ruchi Sharma

National Institutes of HealthORCID 0000-0002-2138-6462Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Ruchi Sharma2 papers · Babraham Institute

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Kapil BhartiiD· 2 shared Ahmed H. GhobashiiD· 1 shared Ajith V. PankajamiD· 1 shared Alexandra–Chloé VillaniiD· 1 shared Ana-Cristina Almansa-GarciaiD· 1 shared Angela ArmentoiD· 1 shared Anjun MaiD· 1 shared Berta de la CerdaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenomics

Kapil BhartiORCID

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2 papers

Recent·Most cited

An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid

Jianming Shao, Xuan Bao, Ismail Yaman, Y Zheng, Jun Wang, Jin Li, Tingting Yang, Jinjing Jian, Jean Li, Seth Blackshaw, Kapil Bharti, Margo S. Clarke, Dwight E. Stambolian, C Sung, Jie Zheng, , Rui Chen

The paper constructs a multi-omics single-cell atlas of human RPE and choroid, identifying cell types, aging patterns, and genetic risk factors for AMD.

bioRxiv · Jul 24, 2026 · PreprintGenomics

The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells

Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango‐González, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernández‐Godino, Berta de la Cerda, Simon J. Clark, Marius Ueffing

This study shows that the CFH Y402H polymorphism increases vulnerability of iPSC-RPE cells to Hydroquinone-induced oxidative stress, suggesting genetic risk predisposition rather than soluble FH effects.

Frontiers in Immunology · Feb 6, 2025Peer-reviewedCell Biology