Progranulin loss induces mitochondrial dysfunction and ferroptosis in human cerebral organoids
Carolina M. Camargo, Maria Camila Almeida, Bárbara Mejía‐Cupajita, Inyoung Hwang, Mohamed A. Faynus, Daniel Carneiro Carrettiero, K S Kosik
This study shows that PGRN loss in human cerebral organoids causes mitochondrial dysfunction and ferroptosis through oxidative stress and iron accumulation.
bioRxiv · Dec 2, 2025 · PreprintNeuroscience