Author

K S Kosik

University of California, Santa Barbara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:mouse· 1

Frequent Co-Authors

Inyoung Hwang· 2 shared Alex SpaethiD· 1 shared Andrew P. LonghiniiD· 1 shared Arina A. NikitinaiD· 1 shared Arthur A. Melo· 1 shared Ash RobbinsiD· 1 shared Athena Quddus· 1 shared Austin DuBoseiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersNeuroscience

Inyoung Hwang

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Author profile →

4 papers

Recent·Most cited

Goal-Directed Learning in Cortical Organoids

Ash Robbins, H. Schweiger, Sebastian Hernandez, Alex Spaeth, Kateryna Voitiuk, David F. Parks, Tjitse van der Molen, Jinghui Geng, Isabel Cline, K S Kosik, Sofie R. Salama, Tal Sharf, Mohammed A. Mostajo-Radji, David H. Haussler, Mircea Teodorescu

This study demonstrates goal-directed learning in cortical organoids using a closed-loop electrophysiology framework and artificial reinforcement learning.

Cell Reports · Feb 1, 2026Peer-reviewedNeuroscience

Progranulin loss induces mitochondrial dysfunction and ferroptosis in human cerebral organoids

Carolina M. Camargo, Maria Camila Almeida, Bárbara Mejía‐Cupajita, Inyoung Hwang, Mohamed A. Faynus, Daniel Carneiro Carrettiero, K S Kosik

This study shows that PGRN loss in human cerebral organoids causes mitochondrial dysfunction and ferroptosis through oxidative stress and iron accumulation.

bioRxiv · Dec 2, 2025 · PreprintNeuroscience

Structure-specific Mini-Prion Model for Alzheimer's Disease Tau Fibrils

Vishnu Vijay, Gregory E. Merz, Karen Tsay, Andrew P. Longhini, Samuel Lobo, Athena Quddus, K. Nakagawa, Michael P. Vigers, Arthur A. Melo, Eric Tse, Shea Joan-Emma, M. Scott Shell, K S Kosik, Daniel R. Southworth, Songi Han

The paper designs synthetic tau fibrils that mimic AD and CTE structures, showing strong seeding ability and catalytic effects in vitro and in cells.

Alzheimer s & Dementia · Dec 1, 2025Peer-reviewedBiophysics

Protective mechanisms against Alzheimer's Disease in APOE3-Christchurch homozygous astrocytes

Xinran Tian, Erica Keane Rivera, Inyoung Hwang, Arina A. Nikitina, Jennifer A. Smith, Youngsuh J. Cho, Julia Sala‐Jarque, Austin DuBose, Clare Andriola, Toby Gollan‐Myers, K S Kosik

This study identifies how APOE3-Christchurch astrocytes protect against Alzheimer's by enhancing tau clearance and reducing harmful lipids.

Alzheimer s & Dementia · Sep 1, 2025Peer-reviewedNeuroscience