Daniel Carneiro Carrettiero

Disrupted Brain Organoid Circuitry, Structural Organization, and Spine Morphology in 7q11.23 Copy Number Variant Syndromes

This study investigates how 7q11.23 copy number variations disrupt brain organoid development, showing structural and functional abnormalities in neural circuits and spine morphology.

BAG2 Condensates Couple Proteostasis to CD8+T Cell Surveillance

This paper identifies I-PDBs as BAG2-driven organelles that link proteostasis to CD8+ T cell surveillance by processing pathological tau into antigenic peptides.

Progranulin loss induces mitochondrial dysfunction and ferroptosis in human cerebral organoids

This study shows that PGRN loss in human cerebral organoids causes mitochondrial dysfunction and ferroptosis through oxidative stress and iron accumulation.

Precision Proteoform Design for 4R Tau Isoform Selective Templated Aggregation

The paper designs a 19-residue peptide that selectively induces aggregation of 4R tau over 3R tau, revealing structural and amino acid determinants of tauopathy propagation.

Methylmalonic acid impairs cell respiration and glutamate uptake in C6 rat glioma cells

This study shows that methylmalonic acid reduces cell viability, impairs energy metabolism, and decreases glutamate uptake in C6 rat glioma cells.