Austin DuBose

This study identifies how APOE3-Christchurch astrocytes protect against Alzheimer's by enhancing tau clearance and reducing harmful lipids.

This paper identifies a tau peptide fragment that forms seeding-competent fibrils and shows how the P301L mutation facilitates its aggregation into 4R tauopathy-like structures.

This paper develops a protein-like polymer that inhibits tau fibril propagation in human-derived models of neurodegeneration by targeting a specific structural motif of 4R tau isoforms.

This study uses NMR to show phosphoryl groups in tau fibrils form ordered 1D wires that stabilize pathological aggregation.

The paper designs a 19-residue peptide that selectively induces aggregation of 4R tau over 3R tau, revealing structural and amino acid determinants of tauopathy propagation.