Julia Sala‐Jarque

Protective mechanisms against Alzheimer's Disease in APOE3-Christchurch homozygous astrocytes

This study identifies how APOE3-Christchurch astrocytes protect against Alzheimer's by enhancing tau clearance and reducing harmful lipids.

Protein-Like Polymer for Inhibition of Tau Fibril Propagation in Human-Derived Models of Neurodegeneration

This paper develops a protein-like polymer that inhibits tau fibril propagation in human-derived models of neurodegeneration by targeting a specific structural motif of 4R tau isoforms.

Precision Proteoform Design for 4R Tau Isoform Selective Templated Aggregation

The paper designs a 19-residue peptide that selectively induces aggregation of 4R tau over 3R tau, revealing structural and amino acid determinants of tauopathy propagation.

Involvement of the cellular prion protein in seeding and spreading of sarkosyl-derived fractions of Alzheimer's disease in Prnp mutant mice and in the P301S transgenic tauopathy mice model

This study investigates the role of cellular prion protein in tau seeding and spreading using Prnp mutant mice and P301S tauopathy models, finding it significant in the latter but not in Alzheimer's sarkosyl-derived samples.