An intrinsically disordered intracellular domain of PIEZO2 is required for force-from-filament activation of the channel
Clément Verkest, Irina Schaefer, Juri M. Jegelka, Timo Albert Nees, Wang Na, Francisco José Taberner, Stefan G. Lechner
This study shows that PIEZO2 detects mechanical forces via two pathways, with the IDR5 domain required for cytoskeleton-mediated force transmission and affecting neurite outgrowth inhibition.
bioRxiv · Jan 13, 2021 · PreprintNeuroscience