Clément Verkest

This study investigates how the wedge domain of PIEZO1 contributes to its inactivation through structural and functional analyses.

This study uses 3D-MINFLUX nanoscopy and electrophysiology to show Yoda1 activates PIEZO1 through two distinct allosteric sites, revealing separate pathways for activation and modulation.

This study uses MINFLUX nanoscopy to show PIEZO1 channels create membrane invaginations and exhibit conformational changes linked to function and cytoskeletal architecture in intact cells.

This study identifies JNK as a post-translational regulator of ASIC1b and ASIC3 channels in sensory neurons, showing its role in pain hypersensitivity.

This study shows that PIEZO2 detects mechanical forces via two pathways, with the IDR5 domain required for cytoskeleton-mediated force transmission and affecting neurite outgrowth inhibition.