Stefan G. Lechner

This study investigates how the wedge domain of PIEZO1 contributes to its inactivation through structural and functional analyses.

This study uses 3D-MINFLUX nanoscopy and electrophysiology to show Yoda1 activates PIEZO1 through two distinct allosteric sites, revealing separate pathways for activation and modulation.

This study uses MINFLUX nanoscopy to show PIEZO1 channels create membrane invaginations and exhibit conformational changes linked to function and cytoskeletal architecture in intact cells.

This study investigates the role of mechanoreceptors and nociceptors in spinal cord injury-induced neuropathic pain, finding that early mechanoreceptor ablation reduces pain behavior, while nociceptor hyperexcitability and sprouting are key drivers of pain.

This study shows that PIEZO2 detects mechanical forces via two pathways, with the IDR5 domain required for cytoskeleton-mediated force transmission and affecting neurite outgrowth inhibition.

This study shows that USH2A is essential for vibration sensing in mice and humans by being expressed in Meissner corpuscle end-organs, not in sensory neurons.

The paper identifies a novel population of sensory neurons that regulate blood pressure through the autonomic nervous system.

This study identifies TrkB-expressing sensory neurons as key to mechanical allodynia and demonstrates their ablation as a treatment for neuropathic pain.