Irineja Cubela

This study creates a perturbation atlas of mouse neural organoids to understand macroglial reactivity and identify drivers of degeneration.

This paper introduces SHOCOs, a modular system using patient-derived colorectal tumor organoids and fibroblasts to model tumor microenvironments, showing improved immune response and stromal effects on therapy.

This paper introduces CORE, a method to align organoid specimens on a shared plane to eliminate sampling bias and enable reproducible histology.

This paper introduces a high-throughput histopathology workflow for complex in vitro models using 3D-printed histomolds, enabling efficient processing and analysis of multiple samples.

The paper introduces a microfluidic platform for high-throughput generation of uniform intestinal organoids in hydrogel droplets, achieving high homogeneity and reproducibility.

The paper introduces a platform for high-throughput spatial phenotyping of multilineage organoids, identifying pathway modulators and treatment strategies for PDAC.

This paper introduces a scalable platform to generate regionally specified neural organoids from uniform single-lumen neuroepithelium, improving reproducibility and fidelity to natural brain development.

The paper develops engineered human gut tissues to study host-microbe interactions and identifies an epithelial gene regulatory network in response to Salmonella Typhimurium infection.

This paper develops human lung alveolar immuno-organoids with autologous immune cells to model immune-epithelial interactions and study inflammation-related pulmonary side effects.