Laura Gaspa-Toneu

This study creates a perturbation atlas of mouse neural organoids to understand macroglial reactivity and identify drivers of degeneration.

The paper measures nucleosome occupancy in mouse and human sperm using single-molecule footprinting and finds species-specific differences in residual nucleosome retention.

This paper introduces a high-throughput histopathology workflow for complex in vitro models using 3D-printed histomolds, enabling efficient processing and analysis of multiple samples.

The paper introduces a statistical model for analyzing single-molecule footprinting data to infer footprint lengths and positions, validated on NOMe-seq datasets from mouse embryonic stem cells.

The paper develops engineered human gut tissues to study host-microbe interactions and identifies an epithelial gene regulatory network in response to Salmonella Typhimurium infection.

This paper develops human lung alveolar immuno-organoids with autologous immune cells to model immune-epithelial interactions and study inflammation-related pulmonary side effects.

This study shows that paternal DNA methylation affects nucleosome retention in sperm and H3K4 methylation deposition in early embryos.