miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing
Isabelle Schiffer, Birgit Gerisch, Kazuto Kawamura, Raymond Laboy, Jennifer E. Hewitt, Martin Sebastian Denzel, Marcelo A. Mori, Siva A. Vanapalli, Yidong Shen, Orsolya Symmons, Adam Antebi
This study shows that miR-1 regulates lysosomal v-ATPase and biogenesis in C. elegans muscle to affect contractility during proteotoxic stress and ageing.
bioRxiv · Jan 21, 2021 · PreprintGenetics