Siva A. Vanapalli

This study shows FHOD-1 and profilin cooperate to stabilize sarcomere Z-lines in C. elegans by promoting actin assembly and preventing muscle deformation during contraction.

This paper develops deep learning methods to detect unstained breast cancer cells in brightfield images containing white blood cells, achieving high sensitivity and specificity.

The paper identifies atracurium as an FDA-approved compound that extends lifespan and healthspan in C. elegans by activating the FOXO/DAF-16 longevity pathway through neuromuscular acetylcholine receptor inhibition.

This study shows that spaceflight causes dendritic remodeling and impaired clearance of neuronal debris in adult C. elegans neurons.

This study shows that miR-1 regulates lysosomal v-ATPase and biogenesis in C. elegans muscle to affect contractility during proteotoxic stress and ageing.

This study shows that swim exercise in C. elegans improves healthspan and protects against neurodegeneration, even when exercise stops early in adulthood.

This paper introduces a Pluronic gel-based burrowing assay to assess neuromuscular health in C. elegans by measuring their ability to navigate a gel environment.