Yidong Shen

Hypomagnetic field inhibits seed germination via ROS signaling and reprogramming transcriptome in Arabidopsis thaliana

This study shows hypomagnetic fields delay Arabidopsis seed germination via ROS signaling and transcriptome reprogramming, involving both CRY-dependent and -independent pathways.

A patient-centric therapeutic paradigm uncouples prostate cancer suppression from systemic metabolic collapse

This paper identifies metabolic dysregulation caused by abiraterone in prostate cancer patients and develops Lifehug-9892 to suppress tumors while preserving systemic metabolic health.

Dynamic dissociation of the IFT complex drives ciliary dysfunction during C. elegans ageing

This study uses super-resolution imaging to show that IFT complexes in C. elegans cilia dynamically dissociate with age, leading to reduced IFT velocity and ciliary dysfunction.

TRiC folds the giant ciliary protein IFT172 via a non-canonical open-state mechanism

This study reveals how TRiC folds the large ciliary protein IFT172 using a non-canonical open-state mechanism involving Z-shaped bending and fold-and-eject dynamics.

miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing

This study shows that miR-1 regulates lysosomal v-ATPase and biogenesis in C. elegans muscle to affect contractility during proteotoxic stress and ageing.