Ishani Morbia

Gene functions determine stochastic or adaptive futile transcription in cancers through deregulated start site deployments

The paper shows that cancer transcriptomes have higher distal TSS deployment and altered energy costs, with gene function determining whether TSS deployment is stochastic or adaptive.

CGGBP1 from higher amniotes restricts cytosine methylation and drives a GC-bias in transcription factor binding sites at repressed promoters

This paper shows that CGGBP1 from higher amniotes restricts cytosine methylation and maintains GC-rich transcription factor binding sites in repressed promoters, influencing TFBS evolution.

The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression

This study shows CGGBP1's DNA-binding domain prevents cytosine methylation at transcription factor binding sites in promoters, regulating gene expression and evolving as a key mechanism in vertebrates.