Umashankar Singh

The paper analyzes FANTOM CAGE data to identify hierarchical TSS co-deployment patterns and shows their disruption in cancers using deep learning.

The paper analyzes 101 amniote genomes to show that CGGBP1 restricts cytosine methylation, preserving G4-forming potential in mammalian and avian promoters through C-T transition rate differences.

The paper shows that cancer transcriptomes have higher distal TSS deployment and altered energy costs, with gene function determining whether TSS deployment is stochastic or adaptive.

This paper shows that CGGBP1 from higher amniotes restricts cytosine methylation and maintains GC-rich transcription factor binding sites in repressed promoters, influencing TFBS evolution.

This study shows CGGBP1's DNA-binding domain prevents cytosine methylation at transcription factor binding sites in promoters, regulating gene expression and evolving as a key mechanism in vertebrates.

The paper introduces a new antibody capture method to accurately capture G4 structures in human cells and shows that G4 formation is constrained by sequence properties and nuclear environment.

The paper investigates chromosomal chimeras in human cell cultures, showing their occurrence at genomic repeats and regulation by stress and CGGBP1 depletion.

The paper shows CGGBP1-dependent CTCF-binding sites inhibit ectopic transcription from the SV40 promoter by acting as transcription barriers.

The paper shows that CGGBP1 regulates cytosine methylation at CTCF-binding sites deterministically, influencing CTCF occupancy and function.

This study shows CGGBP1 regulates CTCF occupancy at repeats and their chromatin barrier function through ChIP-sequencing and histone modification analysis.