Praveen Kumar Issac

This paper shows that CGGBP1 from higher amniotes restricts cytosine methylation and maintains GC-rich transcription factor binding sites in repressed promoters, influencing TFBS evolution.

This study shows CGGBP1's DNA-binding domain prevents cytosine methylation at transcription factor binding sites in promoters, regulating gene expression and evolving as a key mechanism in vertebrates.

The paper constructs a reproductive toxicity knowledge graph (ReproTox-KG) to link birth defects, drugs, and genes, identifying potential molecular mechanisms for drug-induced birth defects.