Akanksha Mudgal

The amniote-conserved DNA-binding domain of CGGBP1 restricts cytosine methylation of transcription factor binding sites in proximal promoters to regulate gene expression

This study shows CGGBP1's DNA-binding domain prevents cytosine methylation at transcription factor binding sites in promoters, regulating gene expression and evolving as a key mechanism in vertebrates.

G-quadruplex landscape and its regulation revealed by a new antibody capture method

The paper introduces a new antibody capture method to accurately capture G4 structures in human cells and shows that G4 formation is constrained by sequence properties and nuclear environment.