MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in ALS-FTD
Ziqiang Lin, Eugene Kim, Mohi U. Ahmed, Gang Han, Camilla Simmons, Yushi T. Redhead, Jack Bartlett, Emiliano Peña‐Altamira, Isobel Callaghan, Matthew A. White, Nisha Singh, Stephen J. Sawiak, Tara L. Spires‐Jones, Anthony Christopher Vernon, Michael P. Coleman, , Jemeen Sreedharan
This study uses MRI and histology to identify structural and cellular changes in TDP-43 knock-in mice, linking them to ALS-FTD pathology and identifying PV+ interneuron loss as a potential biomarker.
Brain Communications · Apr 1, 2021Peer-reviewedNeuroscience