Camilla Simmons

Multiparametric MRI and imaging transcriptomics reveal brain-wide changes in GD3 synthase deficiency

The paper uses MRI and transcriptomic data from a GD3 synthase-deficient mouse model to identify molecular correlates of brain structural differences.

Longitudinal magnetic resonance imaging and spectroscopy in a mouse model of cuprizone-induced demyelination

This paper uses longitudinal MRI/MRS to study demyelination in a mouse model, showing dynamic and partially reversible pathology that correlates with histology.

Multiparametric MRI and imaging transcriptomics reveal molecular and cellular correlates of neurodegeneration in experimental multiple system atrophy

The paper uses imaging transcriptomics in a mouse model of MSA to link MRI patterns with gene expression, identifying molecular correlates of neurodegeneration.

Investigating Brain Alterations in the Dp1Tyb Mouse Model of Down Syndrome

This study examines the brain phenotype of Dp1Tyb mice, a Down syndrome model, revealing neuroanatomical and biochemical alterations compared to wild-type controls.

The effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats

This study investigates the effects of acute Methylene Blue administration on cerebral blood flow and metabolism in humans and rats, finding dose-dependent reductions in CBF and metabolic rates contrary to initial hypotheses.

Mapping neuroinflammation in vivo with diffusion-MRI in rats given a systemic lipopolysaccharide challenge

This study uses diffusion MRI to detect neuroinflammation in vivo in rats after a lipopolysaccharide challenge, showing diffusivity changes correlate with microglial morphology.

Tissue Optimisation Strategies for High Quality Ex Vivo Diffusion Imaging

This paper develops an optimization strategy for ex vivo diffusion imaging in rodent brains to improve signal-to-noise ratio and reduce acquisition time.

Erbb4 deletion from fast-spiking interneurons causes psychosis-relevant neuroimaging phenotypes

This study shows that deleting Erbb4 from PV+ interneurons in mice leads to neuroimaging changes similar to those seen in psychosis patients.

GABAA and NMDA receptor density alterations and their behavioral correlates in the gestational methylazoxymethanol acetate model for schizophrenia

This study examines GABAA and NMDA receptor density changes in MAM-treated rats and their behavioral correlates, finding reduced 5GABAAR and increased NMDA receptor densities linked to schizophrenia-like behaviors.

In vivo multi-parametric manganese-enhanced MRI for detecting senile plaques in rodent models of Alzheimer's disease

This paper demonstrates that multi-parametric manganese-enhanced MRI (MEMRI) can detect senile plaques in rodent AD models, showing manganese binds to plaques in 5xFAD mice but not TgF344-AD rats.

Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder

The paper shows REM and NREM sleep abnormalities and structural changes in GBA1 mice, linking them to RBD and alpha-synucleinopathy progression.

MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in ALS-FTD

This study uses MRI and histology to identify structural and cellular changes in TDP-43 knock-in mice, linking them to ALS-FTD pathology and identifying PV+ interneuron loss as a potential biomarker.

Corticospinal neuroplasticity and sensorimotor recovery in rats treated by infusion of neurotrophin-3 into disabled forelimb muscles started 24 h after stroke

This study shows that delayed peripheral infusion of neurotrophin-3 improves sensorimotor recovery after ischemic stroke in rats by inducing spinal neuroplasticity.