Reactive oxygen species suppress phagocyte surveillance by oxidizing cytoskeletal regulators
Iuliia Ferling, Steffen Pfalzgraf, Lea Moutounet, Lanhui Qiu, Iris Li, Yuhuan Zhou, Sergio Grinstein, Spencer A. Freeman
This study shows that reactive oxygen species (ROS) from IgG-opsonized targets suppress phagocyte surveillance by oxidizing cytoskeletal regulators, leading to cell compaction and podosome disassembly.
bioRxiv · Jan 31, 2024 · PreprintCell Biology